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Michael Antonov: From Virtual World Builder to Real-World Drug Designer

July 1, 2026
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On Behind the Breakthroughs, Deep Origin co-founder Michael Antonov makes the case that real progress in drug discovery comes from pairing machine learning with physics-based simulation and experimental validation — not algorithms alone.

AI is transforming biomedical research, but meaningful advances in drug discovery require more than just increasingly powerful algorithms — they depend on combining machine learning with physics-based simulations, mechanistic models, and rigorous experimental validation. In this episode of Behind the Breakthroughs (Episode 45), Michael Antonov, co-founder of Oculus and computational drug discovery company Deep Origin, shares a pragmatic perspective on AI’s opportunities and limitations in medicine, explaining where it is accelerating innovation and why human expertise and experimental science remain indispensable.

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Produced and hosted by Jonathan D. Grinstein, PhD. Audio mixed and mastered by Erick Ziegler. Brought to you by Inside Precision Medicine (SAGE Publishing).